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A highly sensitive digoxigenin-labeled probe generated using BNA primer for...
A highly sensitive digoxigenin-labeled probe generated using BNA primer for direct measurement of telomeric length in scarce human tumor tissues The main function of telomere is to protect chromosome...
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TRAIP and DNA Repair
Cellular GenomesCellular genomes are very vulnerable to damage during chromosomal DNA replicationcan cause mutations as a result of the incorporation of incorrect bases during DNA replication. For the...
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Octaneuropeptide or ODN protects brain cells
The octadecaneuropeptide (ODN), QATVGDVNTDRPGLLDLK, C81H138N24O29, Mw: 1912.1 g/mol, protects both neurons and astrocytes from oxidative stress-induced cell death. ODN is a neuropeptide similar to...
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Bio-Synthesis, Inc. offers LNA or 2',4'-BNANC based oligonucleotides for...
Bio-Synthesis, Inc. offers LNA or 2',4'-BNANC based oligonucleotides for basic research, genome editing, diagnosis or therapy of multiple human disorders including cancerThe successful development of...
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Antisense oligonucleotides slow the progression of the pediatric...
Antisense oligonucleotides slow the progression of the pediatric neurodegenerative disorder Batten’s disease by correcting mRNA splicing, paving the way for personalized medicineNeuronal ceroid...
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Co-RNA FISH assay employing fluorescently labeled oligonucleotides detects a...
Pancreatic cancer is the 4th leading cause of cancer deaths in the U. S. and may claim ~43,000 lives in this year. Typically, it occurs at ages >45, irrespective of gender. Pancreatic cancer is...
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Single-molecule real-time sequencing (SMRT-seq) with fluorescent...
Neuroblastoma represents the most common cancer for infants less than 1 year old and ~90% are diagnosed at younger than 5 years of age. In humans, nervous system is comprised of ‘central nervous...
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Amino Acid Hydrophobicity for Structural Prediction of Peptides and Proteins
Hydrophobicity refers to the physical property of molecules that repel water. Hydrophobic molecules tend to be nonpolar and therefore prefer to interact other neutral and nonpolar solvents. In water,...
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Monitoring Peptide Binding with a Fluorogenic Probes
Fluorescent probes allow detection of protein location and activation, help identify protein complex formation and conformational changes as well as monitoring biological processes in vivo. Fluorescent...
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Monitoring Peptide Binding with a Fluorogenic Probe
Fluorescent probes allow detection of protein location and activation, help identify protein complex formation and conformational changes as well as monitoring biological processes in vivo. Fluorescent...
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Selective 2’-Hydroxyl Acylation and Primer Extension or SHAPE
Selective 2’-Hydroxyl Acylation and Primer Extension or SHAPEThe majority of RNA molecules only appear to function when they exist in the correct secondary or tertiary structure by folding back onto...
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Primer and Probe Collection for 2019 Coronavirus Detection
Primer and Probe Collection for 2019 Coronavirus Detection The new coronavirus (2019-nCoV) was first detected in Wuhan City, Hubei Province China. Tens of thousands of infections with 2019-nCoV have...
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Towards development of quencher-free oligonucleotide probe with single...
Towards development of quencher-free oligonucleotide probe with single base-discriminating fluorophore enhanced by bridged nucleic acid (BNA) for genotyping SNP (single nucleotide polymorphism) linked...
View ArticleBlocking RNA for Treating Triple Negative Breast Cancer
In 2019, the US National Cancer Institute awarded Bound Therapeutics LLC, together with Thomas Jefferson University and Bio-Synthesis Inc., a Small Business Technology Transfer grant starting 15 June...
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Structure of Coronavirus nCoV 2019/2020
Coronaviruses (CoVs) are enveloped positive-sense RNA viruses. The club-like spikes projecting out from their surface gave them the name. Coronaviruses possess an unusual large RNA genome as well as a...
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Iron Responsive Element RNA or IRE
In humans, iron is a vital trace element. Iron is essential in oxygen transport, oxidative metabolism, cellular proliferation, as well as for many catalytic reactions. Iron metabolism appears to be a...
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RNA cap epitranscriptome analysis reveals novel caps
Almost all naturally occurring types of RNA are post-transcriptionally modified. In general, modifications occur on the nucleobases or ribose, including on the 5'-terminal caps, on messenger RNA...
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BNA gapmers allow selective downregulation of PCSK9 mRNA.
A gapmer oligonucleotide modified with bridged nucleic acids (BNAs) used as an antisense oligonucleotide (ASO) for the reduction of circulating LDL-cholesterol levels lowers the level of hepatic PCSK9....
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The Search for Antitumor Peptides 1 - Target MDM2
The transcription factor p53 regulates many cellular processes, including cell-cycle progression, apoptosis, senescence, DNA repair, and metabolism. Also, p53 is a potent tumor suppressor. Mice that do...
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8- BROMO-2’-DEOXYGUANOSINE and familial amyotrophic lateral sclerosis
8-Bromo-2'-deoxyguanosine, 8-Br-dG, C10H12BrN5O4 , CAS 13389-03-2, 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 8-bromo-2'-dG, 8-Br-2'-dG. Mw:...
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