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8-Bromo-2'-deoxyadenosine
8-Bromo-2'-deoxyadenosine, 8-Br-dA, Mw 330.14 g/mol , CAS 14985-44-5, (2R,3S,5R)-5-(6-Amino-8-bromo-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol. The organobromine compound...
View ArticleCoronavirus Diagnostic Assay 022520
The new coronavirus 2019-nCoV recently identified in patients with acute respiratory disease is genetically similar to SARS coronavirus and bat SARS-like coronavirus. Accurate molecular tests are...
View ArticleRNAs and Cancer Immunotherapy
RNA molecules, including siRNA, microRNA, and mRNA, enable immunomodulation and cancer immunotherapy. Both the innate and the adaptive immune system may respond to challenges from these molucles by...
View ArticlesiRNA, microRNA, mRNA
siRNAsiRNA molecules are approximately twenty-two (22) nucleotides in length and are double-stranded. Initially, siRNA precursors are recognized by Dicer RNase and incorporated into the RNA-induced...
View ArticleNanocarriers for RNA delivery
The extremely short half-lives, poor chemical stability, and natural degradation of RNAs by nucleases resulted in the development of carrier molecules at the nanoscale for RNA delivery into cells....
View ArticleIn vivo delivery of lipophilic siRNA
RNA interference (RNAi) is a conserved biological process for specific silencing of gene expression. Small interfering RNAs (siRNAs) are important tools for the control of gene expression, such as...
View ArticleHotoda’s Sequence and HIV prevention
A modified guanine-rich phosphodiester oligonucleotide prevents HIV-1 infection.The 6mer sequence d(TGGGAG) is commonly called “Hotoda’s sequence”. In the 1990s Japanese researchers studied...
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Proximity ligation assay utilizing fluorescently labeled oligonucleotide...
Proximity ligation assay utilizing fluorescently labeled oligonucleotide probes allows the detection of protein-protein interactions implicated in Alzheimer’s disease (ApoE-C1q) and breast cancer...
View ArticleCoronavirus Inhibitory Peptides
Angiotensin-I-converting enzyme (ACE), also known as peptidyl-dipeptidase A or kininase II, was first isolated in 1956. ACE is a chloride-dependent metalloenzyme. ACE cleaves a dipeptide from the...
View ArticleSpeed-up Identification of COVID19
Bio-Synthesis offers Primers, Probes and Standards to Researchers around the World to help combat the new Coronavirus SARS-CoV-2 (COVID19) and to speed up accurate diagnosis of the virus.Available...
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A Small Angiotensin-Converting Enzyme 2 Inhibitor
NAAE (N- (2-Aminoethly)-1 aziridineethanamine) is a potent angiotensin-converting enzyme two (2) inhibitor. Huentelman et al. in 2004 identified this inhibitor molecule during a molecular docking...
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Messenger RNA (mRNA) for Vaccine Development
Vaccine development based on messenger RNA (mRNA) is a promising new approach. mRNA based vaccine development is potentially very useful to produce vaccines against coronaviruses such as SARS-CoV or...
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Messenger RNA (mRNA) for Vaccine Development Against Coronavirus
Vaccine development based on messenger RNA (mRNA) is a promising new approach. mRNA based vaccine development is potentially very useful to produce vaccines against coronaviruses such as SARS-CoV or...
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Graphical Comparison of Genomes for High-Risk Human Coronaviruses
The following graphic genome depictions of the following coronaviruses are shown: Human SARS CoV-2 (COVID-19), Human coronavirus 229E, Human coronavirus OC43, Human coronavirus HKU1, Human coronavirus...
View ArticleOn the Stability and Infection Risk of SARS-CoV-2 (COVID-19)
Respiratory viruses such as the new coronavirus SARS-CoV-2 are not very stable. Destroying the lipid coating of the shell will prevent infection by the virus.Respiratory viruses such as the new...
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Polyprotein processing of SARS Coronaviruses
Bio-Synthesis Inc. is pleased to offer a large variety of RNA molecules (both synthetic and enzymatically derived) for a number of research applications, including COVID 19 testing and analysis !We...
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Coronavirus Specific Peptide Libraries or Pools
Peptide libraries or pools allow the stimulation of SARS-CoV-2 (COVID-19) specific T cells to develop therapeutic vaccines or drugs. After successful stimulation, T cells can be detected and isolated...
View ArticlePotential Peptide Targets for a COVID-19 Vaccine
Since the emergence of the COVID-19 outbreak, there is a great need to understand the molecular biology and immunogenicity of the SARS-CoV-2 virus to enable the development of potent vaccines. To help...
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Increased risk for COVID-19 infection in cancer patients with weakened immune...
Increased risk for COVID-19 infection in cancer patients with weakened immune system: Bio-Synthesis, Inc. offers Synthetic RNA Controls, primers and probes for COVID-19 diagnosisThe beginning of the...
View ArticleFluorogenic oligonucleotide probes for allelic discrimination of coronaviruses
Sequence analysis of SARS-coronavirus isolates performed by Chung et al. in 2005 revealed that specific genotypes predominated at different periods of the SARS 2002-2003 epidemic. The availability of...
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