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Members of the “Self-Avoiding Molecular Recognition Systems” or SAMRS bind to...
Self-avoiding molecular recognition systems (SAMRS) prevent the binding or interaction of similar molecular analogs with each other.Because of the enormous diversity of pathogens, pathogen detection...
View ArticleEffects of Modifications on Nucleic Acid Properties
Modifications of nucleic acids can alter their physical properties, stability, interaction potential, and biological function. Naturally modified nucleic acids regulate vital cellular processes,...
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Bioconjugation for Nucleic Acids Drug Conjugates and Therapeutics
The bioconjugation field continues to grow, making bioconjugation technics important and essential in biotechnology, molecular biology, medicine, and materials science. Bioconjugation methods enable...
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Phosphorodiamidate Morpholinos and Thiomorpholinos for Therapeutic...
Morpholino Types for Therapeutic OligonucleotidesMorpholinos are synthetic molecules utilized in antisense morpholino-based oligonucleotides designed to bind to specific RNA sequences to block...
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Peptide-Oligonucleotide Conjugates (POCs) for Oligonucleotide Delivery
Peptide-Oligonucleotide conjugates (POCs) are synthetic molecules, in which a peptide is conjugated to an oligonucleotide, for example, a linear or cyclic peptide linked by a covalent bond or linker to...
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Diagnostic DNA-Alanyl-PNA chimeras
DNA-Alanyl-PNA chimeras are oligomers combining peptide nucleic acids (PNAs) and DNA oligonucleotides for the creation of new molecules with improved properties and a potential to be beneficial in DNA...
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Non-linking Phosphorous Backbone Modifications For Enhanced Therapeutic...
Non-linking phosphorus backbone modifications are chemical changes made to the phosphodiester backbone of oligonucleotides to modify their stability, binding affinity, and resistance to enzymatic...
View ArticleTumor Targeting or Tumor Homing Peptides
Cancer is a complex tissue containing a multitude of stromal cells as well as extracellular matrix. Hence, targeting the microenvironment of a tumor or cancer cell may allow destroying the malignant...
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Circular RNA or Cyclic RNA could be used in diagnostics, therapeutics, and...
As research progresses, circular RNAs (circRNAs, also known as cyclic RNAs) have the potential to revolutionize diagnostics, therapeutics, and biotechnology. Small circRNAs are non-coding RNAs...
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Tricyclo-DNA or tcDNA Modified Therapeutic Oligonucleotides
Tricyclo-DNA (tcDNA) is a synthetic nucleic acid analog modified with a rigid tricyclic structure in the sugar backbone. This modification enhances the properties of nucleic acids. Due to its...
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