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Coronavirus SARS-CoV-2 Proteases
Coronaviruses (CoVs) are enveloped positive-sense RNA viruses. CoVs contain a large genome, usually 25 to 32 kb, and can infect a variety of species, including animals and humans. Infections by CoVs...
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Coronavirus SARS-CoV-2 and ISGylation
ISGylation, the modification of protein targets by the interferon-stimulating gene protein 15 (ISG15), involves a cascade of enzymatic reactions utilizing the ubiquitin-activating enzymes E1, E2, and...
View ArticleCan coronavirus SARS-CoV-2 invade T cells?
A recent paper published by Wang et al. suggest that this is the case. The SARS-CoV-2 (COVID-19) virus uses the human angiotensin-converting enzyme 2 (ACE2) as the receptor for its entry into cells....
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FDA approves first-ever siRNA oligonucleotide drug for neurodegenerative...
FDA approves first-ever siRNA oligonucleotide drug for neurodegenerative disorder raising the prospect for cancer or COVID-19 therapy: Bio-Synthesis, Inc. offers Synthetic RNA Controls, primers and...
View ArticleAbbreviations commonly used in corona virus research
Abbreviation Description ACE Angiotensin-converting enzyme.ACE2 Angiotensin-converting enzyme 2.APN Aminopeptidase.ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide.COPB2 Coatomer protein...
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Efficient delivery of therapeutic RNA
The efficient delivery of RNA molecules into cells or tissue, such as siRNAs, is a necessity for the development of therapeutic RNAs. For many years, the difficulty encountered in efficient and safe in...
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Texan Bats and Coronaviruses
When watching bats in Austin, Texas at the South Congress Bridge, one does not think that these critters carry a coronavirus. The emergence of the Mexico free-tail bats every evening from March to...
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Endocytic trafficking inhibitors: ongoing clinical trials assess...
To date, hundreds of different species of cornaviruses have been identified, which infect a variety of organisms. For the poultry industry, a significant economic loss has been associated with avian...
View ArticleRemdesivir and COVID-19
As of May 04, 2002, according to the John Hopkins University, more than 3.5 million people have tested positive for the coronavirus worldwide, and over 248,000 people have died. Therefore, effective...
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The SARS-CoV-2 Envelope Protein
Coronaviruses are known to cross the species barrier and infect humans. The recent outbreak of SARS-CoV-2 (COVID-19) is a vivid example. The outbreaks of SARS in 2003 and, more recently, Middle-East...
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FDA approves first-ever siRNA oligonucleotide drug for neurodegenerative...
‘RNA interference’ refers to a defense mechanism developed to counter the invading viruses at the RNA level (Agrawal et al., 2003). The post-transcriptional gene silencing mechanism was originally...
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Endocytic trafficking inhibitors: ongoing clinical trials assess...
To date, hundreds of different species of cornaviruses have been identified, which infect a variety of organisms. For the poultry industry, a significant economic loss has been associated with avian...
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SARS-CoV-2 (COVID-19) FRET Peptides
Fluorescence‐based peptide assays allow screening of protease inhibitor compounds in a high throughput format. Fluorescence resonance energy transfer (FRET) peptides are useful tools for the study of...
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Therapeutic strategies to counter COVID-19 coronavirus or cancer though...
Recent works have allowed a greater advancement in our understanding of the mechanism regulating immune response at the molecular level. This, in turn, has led to improved modulation of the...
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Potential application of minor groove binders for cancer therapy or COVID-19...
Given the expanding scope of infection, the origin of recently emerged COVID-19 coronavirus remains a topic of interest to both scientists and the public at large. Identifying the origin of COVID-19...
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siRNAs or interference RNA for COVID-19
RNA interference as a technology allows knocking down genes after transcription. RNA interference can potentially allow selective knocking down or silencing of targeted SARS-CoV-2 (COVID-19) genes....
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Standards for Industry and Research
GLP, GMP, cGMP, ISO 2001:2015 and ISO 13485 Business technologies usually adhere to a set of standards and best practices. International organizations such as the International Organization for...
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Vaccination with neoantigenic peptides or RNA may extend the survival of...
The recent years have seen the development of multiple innovative treatments for cancer to complement standard therapies consisting of surgery, radiotherapy and chemotherapy. These include targeted...
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Very Fast CRISPR using Caged Deoxythymidine
A very fast CRISPR method employing caged RNA (vfCRISPR) allows Cas9 to bind DNA without cleaving the targeted DNA until activated by light. Liu et al. recently designed a Cas9 CRISPR system that...
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What is a carrier molecule?
A carrier molecule is typically involved in the transport of other biological compounds such as proteins, DNA or RNA, electrons, or protons including ions. For example, carrier proteins can transport...
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