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Antiviral peptides for SARS-C0V-2 (COVID-19)
The surface spike (S) protein is essential for coronavirus binding and entry into host cells. Molecular biology studies indicate that the heptad repeats 1 and 2 (HR1 and HR2) in the S protein induce...
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Peptide therapeutics target dynamic protein-to-protein interaction underlying...
Increasingly, peptide-based drugs are finding utility in medicine. This is not surprising given that many of the physiological processes are carried out by endogenously expressed peptides, ex....
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Innate Immunity, RNA Sensing and COVID-19
The recent COVID-19 pandemic has rapidly expanded to infect more than 14 million people by July 21, 2020, and has had a significant impact on our lives. The innate immune system is one of the first...
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mRNA vaccines and innate immunity
Vaccination prevents many millions of illnesses and saves many lives every year. The smallpox virus vaccine is an excellent example of a successful vaccination approach. Messenger RNA (mRNA) vaccines...
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Liquid biopsies containing circulating tumor DNA (ctDNA) for diagnosing...
Biomarkers play an indispensable role for cancer management. Biomarkers include specific molecules or genetic mutations whose presence is indicative of the disease progression. One major area of its...
View ArticleUseful RNA Databases
RNA databases contain sequences and useful tools for the analysis of RNA molecules and to enhance RNA research.RNAcentral RNAcentral - RNAcentral About-us The non-coding RNA sequence database : a...
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2’-Fluoroinosine, a Replacement for Inosine
Modified oligonucleotides allowed researchers to gain insight into conformational, mechanistic and sterochemical aspects of a variety of biological reactions and processes. Using 2'-Fluoroinosine...
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Triplex Formation for the Detection of microRNAs
MicroRNAs (miRNAs) are short RNA oligonucleotides with an average length of 22 nucleotides. miRNAs play essential roles in many biological processes, including cell development, proliferation,...
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Development of a simplified RNA extraction method incorporating...
The unprecedented emergence of a pandemic caused by COVID-19 coronavirus has taken a toll socially as well as economically. Its impact has been felt globally as the virus moved on from continent to...
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Linear Polyacrylamide as a Carrier Molecule during Alcohol Precipitation
Linear polyacrylamide can be used as a carrier molecule during alcoholic precipitation.Adding linear polyacrylamide as a neutral carrier to ethanol precipitations is more advantage than using other...
View ArticleMemory T cells remember coronavirus infections
Viral infections can induce memory T cells in humans. A previous infection can influence the course of a new viral infection.As a response to pathogens, naive T cells rapidly divide and express...
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Evaluating the efficacy of RT-PCR in assessing infectivity, accuracy of death...
The current strategy to manage the COVID-19 pandemic relies heavily on the accuracy of the existing diagnostic methods to detect the presence of its genomic RNA. However, even with RT-qPCR, it yields...
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Therapeutic Peptides for SARS-CoV-2 (COVID-19)
Peptide-based therapies offer a cost-effective and rapidly developed therapeutic response to pandemic outbreaks such as COVID-19. However, one drawback is their proteolytic instability....
View ArticleŇuña Bean Protein Characterization
Ňuña beans, or Andean popping beans, are the lost food of the Incas. The ñuña bean is an Andean subspecies of Phaseolus vulgaris, Phaseolus vulgaris ñuñas (Phaseolus vulgaris L.). The seeds of ñuña...
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Terminal Deoxynucleotidyl Transferase, also known as the Bollum Enzyme
Terminal deoxynucleotidyl transferase (TdT; EC 2.7.7.31) is a DNA polymerase that elongates DNA strands template-independently and incorporates both ribo- and deoxy-ribonucleotides and many other...
View ArticleCOVID-19 Antibody Detection and Prevalence
Immunoassays allow the determination of antibody responses against the severe acute respiratory syndrome coronavirus (SARS-Cov-2; COVID-19). Specifically developed immunoassays detect immunoglobulin M...
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'CDK4/6 inhibitors' targeting retinoblastoma (Rb) protein to block cell...
October is the breast cancer (affects ~13% of women in the U. S.) awareness month and we have come a long way as 5-year survival rate for localized and regional cases (cancer cells spread to nearby...
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DNA oligonucleotide labeling using 4-thiouridine
The enzyme “terminal deoxynucleotidyl transferase” (TdT) adds several ribonucleotide residues to DNA fragments or primers. TdT can add deoxynucleotidyl triphosphates (dNTPs) randomly to the 3’-hydroxyl...
View ArticleSelf-priming DNA or what is self-priming?
What is self-priming?Self-priming refers to the folding back of oligonucleotides. Self-priming allows amplification initiation without the need for an additional primer, a short, single-stranded DNA...
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Can a lipopeptide based nasal spray prevent COVID-19?
In ferrets, a nasal spray prevents COVID-19 infection. Can a similar nasal spray for humans do the same? It appears that this is the case. In comparison to monoclonal antibodies lipopeptide or...
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