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Can single messenger RNAs (mRNAs) be tracked inside live cells?
Can single messenger RNAs (mRNA) be tracked inside live cells?The answer is yes!In recent years, single-cell biology has revealed that each cell is unique. However, single cells can vary significantly...
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Streptide, a newly discovered naturally occuring cyclic peptide
Streptide is a newly discovered macrocyclic naturally occurring streptococcal peptide.Streptococcal bacteria are thought to use peptides as communication signals. Often these types of peptides contain...
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Teixobactin, a new antibiotic peptide that has the potential to avoid the...
Teixobactin is a newly discovered natural occurring antibiotic peptide.Teixobactin is a newly discovered antibiotic peptide identified from soil samples using isolation chip (iChip, Ichip, or ichip)...
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Cancer genes and food that fight cancer
News from the Annual Meeting of the American Association for Cancer Research (AACR) 2015 held in Philadelphia April 18 – 22, 2015 at the Pennsylvania Convention Center, Philadelphia,...
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How does the BNA bead-based assay for somatic mutations work?
Shivarov et al. designed and validated this BNA[NC] probe bead-based assay for the Luminex Lab Scan 200 flow platform to allow for the detection and quantification of somatic mutations in...
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A novel BNANC bead-based assay for somatic mutations in Leukemia
Shivarov et al. designed and validated a novel bead-based suspension assay using BNA[NC] probes for the Luminex Lab Scan 200 flow platform to detect and quantify somatic mutations in...
View ArticleWeb resources for the CRISPR Cas System
Drosophila CRISPR Web ResourcesName LinkDescriptionOxfCRISPR(Liu Lab)http://www.oxfcrispr.orgOxford Fly CRISPR ResourcesCRISPRflydesign (Bullock Lab)http://www.crisprflydesign.org/Offers Cas9...
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How can the CRISPR Cas System be used?
Potential Uses or Applications of the CRISPR Cas System !Several Uses of Cas9 Induced Double Strand Breaks for Genomic Engineering as Suggested by Basset and Li in 2014 are listed below.Most...
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Structural Models of the CRISPR Cas System
As of December 2013 90 solved structures were available in the PubMed structural database related to the CRISPR Cas System! A few these models are shown below!A PubMed search for “CRISPR Cas” showed...
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Highlighted Reports on the CRISPR Cas System
Selected papers for CRISPR Cas!Segal and Meckler in 2013 state in ‘Genome Engineering at the Dawn of the Golden Age,’ that, “In summary, compared with ZFNs, TALENs can be designed for more targets, are...
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Is Targeted Insertion of Short DNA Fragments into Mammalian Cells Possible
Recently the Targeted Insertion of Short DNA Fragments into Mammalian Cells was Shown to be Possible with the help of CRISPR Cas!The direct injection of Cas9 mRNA, sgRNAs, and DNA oligos or vectors...
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What is a CRISPR Cas system?
The CRISPR-Cas systems found in bacteria and archaea are versatile small RNAs for adaptive defense and regulationBacteria and archaea have evolved various defense and regulatory mechanisms allowing...
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How do we taste or smell odors?
The taste of sugars amino acids, peptides, nucleotides, and proteins“Analytical Services”Taste and smell are chemical senses that give us humans and many animals information about the chemical...
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TRF Analysis of Telomeres using BNA Probes
In aging humans, the length of telomeres declines in dividing cells. Each time cells divide, telomeres can get shorter. When the telomeres are too short, the cells can no longer divide. The cells...
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Why do we need cell line identification and authentication?
Why do we need cell line identification and authentication? As reported in the literature, cell lines are frequently contaminated or misidentified. A high percentage of cell lines are...
View ArticleCarnosine (β-Ala-L-His)
Carnosine (β-Ala-L-His) The dipeptide carnosine is a bioactive endogenously abundant peptide. High amounts of carnosine are found in muscle and brain tissues. A Russian scientist with the name of...
View ArticleExplanation of Bioanalytical Methods and Analytical Services
Bioanalytical Methods and Analytical Services To fully characterize biological samples or compounds such as amino acids, carbohydrates, vitamins, metabolites, oligonucleotides, peptides, and proteins a...
View ArticleMyristoylated peptides are candidates for drug design
Myristoylated peptides are candidates for drug design! Myristoylation of proteins or peptides is a posttranslational modification found in eukaryotic and viral proteins in which the N-terminal end is...
View ArticleTherapeutic nucleoside and nucleotide analogs
Since the development and introduction of solid phase oligonucleotide synthesis in the 1950s several nucleoside and nucleotide analogs have been identified as potent antiviral drugs. These compounds...
View ArticleHow is Extinction Coefficient Determined for Proteins
How are extinction coefficients determined for Proteins? Extinction coefficients for proteins are determined at absorbance maxima near 280 nm. Protein analysis is needed to determine if a sample...
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