N6-methyladenine is a newly discovered epigenetic mark in eukaryotes..
N6-methyladenosine is a modification found in eukaryotic mRNAs and long non-coding RNAs. Recent research indicates that N6-methyladenosine is part of a controlling mechanism that regulates cellular...
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What are Alarmones?
Alarmones are nucleotide-based second messengers that respond to environmental changes in bacteria and plant chloroplasts. The nucleotides guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate...
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What are Temporin Peptides?
Temporins or temporin peptides are frog peptides that belong to a family of short hydrophobic peptides with antibacterial and antifungal properties. Temporins are 10 to 17 amino acids in length and...
View ArticleD-Aspartic acid in mammals and humans!
D-Aspartic acid (D-Asp, D-D) is an endogenous amino acid found in nervous and endocrine tissues in mammals including humans. Embryos contain a high concentration of D-Asp which decreases after birth....
View ArticleD-Aspartic Acid as a supplement
Recently D-Aspartic Acid has been suggested as a supplement to boost testosterone levels in infertile men as well as in athletes. However, given the limited published literature, further research is...
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RNA Structures
RNA StructuresAn RNA StructureIs made up ofPhosphate in a diester linkageRibose Bases Adenine, Uracil, Cytosine, GuanineproduceRibonucleotidesPolymers formrRNAribosomal RNAtRNAtransfer RNAEukaryotic...
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Labeling and Protecting Groups used in Peptide Synthesis
Labeling and Protecting Groups used in Peptide SynthesisIn a peptide, each monomer unit in the sequence chain is known as an amino acid residue. The term residue refers to the fact that each amino...
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List of license free fluorescent dye oligo Labeling
Bio-Synthesis offers wide variety of fluorescent dyes for oligonucleotide or peptide labeling. IP-Free dyes are fluorophores with no patent licensing restrictions to use for commercial or diagnostic...
View ArticleMERFISH is used for single-cell gene-expression profiling
Multiplexed error-robust fluorescence in situ hybridization (MERFISH) is a massively parallelized form of the single-molecule fluorescence in situ hybridization (smFISH) method that can image and...
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Designing readout probes
What is a readout probe?In general, any oligonucleotide probe that allows for the detection or readout of a complementary target sequence is a “readout probe.” Readout probes are useful tools for in...
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TRF Analysis of Telomeres using BNA Probes
In aging humans, the length of telomeres declines in dividing cells. Each time cells divide, telomeres can get shorter. When the telomeres are too short, the cells can no longer divide. The cells...
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Why do we need cell line identification and authentication?
Why do we need cell line identification and authentication? As reported in the literature, cell lines are frequently contaminated or misidentified. A high percentage of cell lines are...
View ArticleCarnosine (β-Ala-L-His)
Carnosine (β-Ala-L-His) The dipeptide carnosine is a bioactive endogenously abundant peptide. High amounts of carnosine are found in muscle and brain tissues. A Russian scientist with the name of...
View ArticleExplanation of Bioanalytical Methods and Analytical Services
Bioanalytical Methods and Analytical Services To fully characterize biological samples or compounds such as amino acids, carbohydrates, vitamins, metabolites, oligonucleotides, peptides, and proteins a...
View ArticleMyristoylated peptides are candidates for drug design
Myristoylated peptides are candidates for drug design! Myristoylation of proteins or peptides is a posttranslational modification found in eukaryotic and viral proteins in which the N-terminal end is...
View ArticleTherapeutic nucleoside and nucleotide analogs
Since the development and introduction of solid phase oligonucleotide synthesis in the 1950s several nucleoside and nucleotide analogs have been identified as potent antiviral drugs. These compounds...
View ArticleHow is Extinction Coefficient Determined for Proteins
How are extinction coefficients determined for Proteins? Extinction coefficients for proteins are determined at absorbance maxima near 280 nm. Protein analysis is needed to determine if a sample...
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The Maillard reaction and Amadori rearrangement
The Maillard reactionThe Maillard reaction is a complex set of chemical reactions between amines and carbonyl compounds such as sugars to ultimately form Amadori products.The following scheme shows a...
View ArticleWhat are Signature Peptides
What are Signature Peptides?Signature peptides are unique tags or biomarkers, detected as molecular markers or as unique sequence tags. Signature peptides are useful tools for biomarker discovery and...
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