The Genetic Code and its Nomenclature
The Genetic Code and its Nomenclature The genetic code is a set of rules mapping codons to amino acids. This is the alphabet used to encode genetic information for the synthesis of proteins. • There...
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Applications for synthetic gene fragments
Applications for synthetic gene fragments Since the development of modern molecular biology, cells, and their structures have been studied in detail. It has now become apparent that highly organized...
View ArticleHaloTag® fusion proteins and conjugates for cell imaging
HaloTag® fusion proteins and conjugates for cell imagingBy Klaus D. Linse The HaloTag® fusion protein technology can be used to design and prepare fusion proteins, fusion protein conjugates, and...
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Chemically Modified Nucleic Acids for CRISPR-Cas
Chemically Modified Nucleic Acids for CRISPR-CasChemically modified nucleosides are useful for the enhancement of genome editing efficiency when using the CRISPR-Cas systems. Recently scientists...
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Genome editing using CRISPR systems
Genome editing using CRISPR systems The CRISPR systems based gene editing method has been named the breakthrough technology of the year 2015 by the Journal Science. This gene editing method known as...
View ArticleA sensitive diagnostic test for the detection of mutations in chronic...
A sensitive diagnostic test for the detection of mutations in chronic lyphocytic leukemia Recently a research group at the NIH in collaboration with NeoGenomics Lab in California developed a sensitive...
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What is Carrier-Induced Epitope-Specific Suppression
Conjugated Antigens The problem of Carrier-Induced Epitope-Specific Suppression (CIESS)“Carrier-Induced Epitope-Specific Suppression is a hapten-specific immune suppression that is induced following...
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Messenger RNA in Gene expression
Messenger RNA in Gene expression Gene expression refers to the conversion of genetic information from genes via messenger RNA to proteins. The entire set of genes in an organism is called the...
View ArticleDrug Conjugation Synthesis Strategies
Drug Conjugation Synthesis StrategiesOne of the most effective ways to deliver cytotoxic drugs is by conjugation, where a relatively small molecular weight drug is covalently linked to usually a...
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The role of mRNA in Gene Expression
The role of mRNA in Gene expression Gene expression refers to the conversion of genetic information from genes via messenger RNA (mRNA) to proteins. The entire set of genes in an organism is called the...
View ArticleVaccine adjuvants that induce an immune response
Inducing a deliberate immune response with vaccine adjuvants Despite all of the recent advances in innate immunity and immune modulators or vaccine adjuvants, the induction of an immune response...
View ArticleZika Virus Update February 2016
Zika Virus – an update The Obama administration requested $1.8 billion in emergency funds to combat the Zika virus in early 2016 according to the journal CEN (CEN.ACS.ORG February 15, 2016). This money...
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Zika Virus Genome and Infections
Zika Virus Genome and Infections The recent outbreak of the Zika virus in Brazil and its projected spread into other countries has put the spotlight on this virus. Since this is a newly emerged virus...
View ArticlePrimers and Probes for Zika Virus Detection
Primers and Probes for Zika Virus Detect Current molecular assays for flaviviruses use specific primers to amplify viral RNA for their detection. If these primers are to specific they may amplify RNA...
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Segmental Labeling of RNA with Stabile Isotpes
Segmental Labeling of RNA with Stabile IsotpesDuss et al. in 2010 developed a method using 13C and 15N labeled nucleoside triphosphates (NTPs) for the labeling of RNA. RNA molecules are frequently...
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Segmental Labeling of RNA with Stable Isotopes
Segmental Labeling of RNA with Stable IsotopesDuss et al. in 2010 reported the development of a method using 13C and 15N labeled nucleoside triphosphates (NTPs) for the segmental labeling of RNA with...
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Gapmer Design
Gapmer Design A gapmer is a chimeric antisense oligonucleotide that contains a central block of deoxynucleotide monomers sufficiently long to induce RNase H cleavage.General Design The central block...
View ArticleMasses of Common Elements
Masses of Common Elements Mass spectrometry is a powerful analytical technique often used for the identification of unknown compounds such as small organic molecules, nucleotides, oligonucleotides, and...
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What is a Phosphodiester bond?
What is a Phosphodiester bond?A phospodiester bond is a covalent bond in which a phosphate group joins adjacent carbons through ester linkages. The bond is the result of a condensation reaction between...
View ArticleSOME FACTS ABOUT ANTIBODY-DRUG CONJUGATES
SOME FACTS ABOUT ANTIBODY-DRUG CONJUGATESAntibody-drug conjugates (ADC) are composed of two moieties covalently linked:An antibody that usually is a monoclonal antibody (mAb) and that acts as the...
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