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Antiviral Peptides
Many peptides have been reported to prevent viral attacksWouldn’t it be great if foods or drinks enabled us humans to prevent viral or bacterial infections? Or, if nasal or oral spray containing...
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The Chemical Synthesis of Oligonucleotides
The Chemical Synthesis of OligonucleotidesBy Andrei Laikhter and Klaus D. LinseThe study of nucleic acids has now become a fruitful and dynamic scientific enterprise. Nucleic acids are of unique...
View ArticleAldehyde Modified Oligonucleotides
Aldehyde modified oligonucleotides, their broad utility in bio-conjugation applications and surface attachment methods.In recent times both basic and applied molecular biology studies have made...
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Inheritance of Epigenetic Defects
Epigenetics and the inheritance of epigenetic defectsBy Klaus D. LinseHave you ever wondered if where you grew up and where you lived or live now, what you eat and what you do had or has an influence...
View ArticleRetro Inverso Peptides
Retro-inverso peptides are linear peptides whose amino acid sequence is reversed and the α-center chirality of the amino acid subunits is inverted as well. Usually, these types of peptides are...
View ArticleWhat is an antibody-drug-conjugate or ADC? It is an antibody molecule...
Antibody-drug conjugates, also called ADCs, are site-specifically modified antibodies that are designed as a targeted therapy for the treatment of cancer and are considered as a new class of highly...
View ArticleProtein Moonlighting
Protein moonlighting or gene sharing refers to the phenomenon by which proteins perform multiple functions in an organism. A big surprise as a result of sequencing the human genome was the discovery...
View ArticleCollagen Mimetic Peptides
By: Klaus D. Linse Collagen mimetic peptides, or CMPs, are typically made of 30 or fewer amino acids. These types of peptides are usually composed of multiple helix promoting peptide trimers. Collagens...
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Gold Nanoparticle Properties
Gold nanoparticles (colloidial gold) have been extensively used for applications both in biology (e.g. bio-imaging) and technology (e.g. photonics) due their unique optical properties. These properties...
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Gold Nanoparticles Handling and Storage
Storage:Store product away from direct sunlight at 4-25°C. Lower temperature prolongs the shelf life of the product. Do NOT freeze. If frozen, the gold nanoparticles will irreversibly aggregate. This...
View ArticleAdsorption of Proteins to Gold Nanoparticles
Gold nanoparticle conjugates have been used for a wide range of biological applications including the use as probes in light and electron microscopy. Stable gold nanoparticle conjugates can easily be...
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Immunoblotting | Immunogold Dot-Blot
Due to the relative ease of preparing antibody gold conjugates, and straightforward detection of gold nanoparticles by naked eye without prior development procedures, these probes has found great use...
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Lateral Flow Immunoassays
While rapid assay methods have made a major impact on a variety of diagnostic testing over the last twenty years only a handful of development can make the claim to have taken testing out of the...
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Gold Nanoparticle Surface Design
Gold nanoparticles have many applications in biology and medicine. Gold nanoparticles are used as biosensors, cellular probes, drug delivery vehicles, or as optical contrast agents (1). To use gold...
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Silver Nanoparticle Properties
Silver nanoparticles (colloidal silver) have unique optical, electronic, and antibacterial properties, and are widely used in areas such as biosensing, photonics, electronics, and antimicrobial...
View ArticleSilver Nanoparticles Handling and Storage
Storage:Store silver nanoparticles at 2-8°C and protected from light. Do NOT freeze. If frozen, the silver nanoparticles will irreversibly aggregate. Aggregation of silver nanoparticles is indicated by...
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Conjugation of Proteins to Silver Nanoparticles
Silver nanoparticle conjugates are useful for a wide range of biological applications including bio-sensing and bio-imaging. Stable silver nanoparticle conjugates can be prepared by two general...
View ArticleOligonucleotide Quantitation Using Spectrophotometry
Spectrophotometry allows for the quantitative measurement of molecular compounds or substances by measuring the quantitative reflection or transmission properties of matter as a function of a specific...
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Carboxyl modified oligonucleotides and utility in bio-conjugation...
Peptide linker is the most common attachment method in bio-conjugation 1-3 and between various biopolymers. That approach requires one biopolymer or a surface having an amino function and another...
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Delta Sleep Inducing Peptide (DSIP)
By Klaus D. Linse Delta sleep inducing peptide, or DSIP, is a nonapeptide with the sequence WAGGDASGE and a molecular weight of 849 dalton. The peptide was discovered by G. Schoeneberger and M. Monnier...
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