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Homocitrulline

Homocitrulline Homocitrulline, also known as L-Homocitrulline, N(6)-carbamoyl-L-lysine, N(6)-(amino-carbonyl)-L-lysine, (2S)-2-amino-6-(carbamoyl-amino) hexanoic acid, has the molecular formula...

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Amino Acid Analysis of Homocitrulline

Homocitrulline with the molecular formula C7H15N3O3, and a molecular weight of 189.2123 daltons, can be analyzed using amino acid analysis. Molecular models for homocitrulline are shown below.  Figure...

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Several structures of myelin oligodendroyte glycoprotein or MOG have been solved

 Several structures for MOG have been solved! MOG or myelin oligodendrocyte glycoprotein is a key central nervous system (CNS)-specific autoantigen for primary demyelination in multiple sclerosis. The...

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Antibody Drug Conjugates - A new way to treat cancer

 Antibody drug conjugates- a new way to treat cancer By Klaus D. LinseThe approval of rituximab, a chimeric monoclonal antibody (mAB) that recognizes the CD20 protein, in 1997 by the U.S. Food and Drug...

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Biotin - a water-soluble Vitamin

Biotin- a water-soluble Vitamin Biotin is a water-soluble vitamin that functions as a coenzyme for five mammalian carboxylases: pyruvate carboxylase (EC 6.4.1.1), propionyl-CoA carboxylase (EC...

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Growth Hormone

Growth Hormone Growth hormone or somatotrophin is a naturally occuring peptide hormone, a polypeptide or small protein that contains a single chain polypeptide which amino acid sequence is made up of...

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Human Growth Hormone (HGH)

Human growth hormone or hGH Human growth hormone (hGH) is a naturally occurring peptide or protein hormone secreted by the pituitary gland. Growth hormone (GH or HGH) is also known as somatotropin or...

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Amino acids are stereo-isomers, posses handedness and are chiral molecules

Amino acids are stereo-isomers, posses handedness and are chiral molecules Molecules with the same atoms and functional groups are called stereoisomers.  Stereoisomers are compounds made up of the same...

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Different Attachment Linkers for Oligonucleotide Conjugation

Traditionally amino and sulfhydryl groups attached to oligonucleotides have been the most common functionalities employed in bio-conjugation.1.2 That kind of attachment chemistries have been adopted...

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A Collection of Protein Precipitation Methods for Proteomics

 A Collection of Precipitation Methods for ProteomicsBy Klaus D. LinseProtein precipitation methods are used for the concentration of diluted proteins in solution. The goal is to purify and concentrate...

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Click Chemistry - A Review

Click Chemistry - A ReviewClick chemistry refers to a modular chemical approach that utilizes the copper (I) catalyzed 1,2,3-triazole formation from azides and terminal acetylenes as a powerful linking...

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Gene Expression

Gene ExpressionGene expression is the most fundamental process that organisms undergo to perform the cellular functions required for life.  Gene expression can also be manipulated in the lab to take...

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DaOligonucleotide Fluorescent Labeling

Oligonucleotide Fluorescent Labeling By Andrei LaikhterOptimally labeled nucleic acids are used as molecular probes and are very useful for a variety of nucleic acid based applications such as in...

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Western Blot

Western Blot The western blotting technique was developed in 1979 by Towbin.  The system received its name from the step where a protein is “blotted” from a gel onto a membrane and as a spinoff from...

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The Ebola Virus Genome and Proteome

The Ebola Virus Genome and ProteomeThe Ebola virus is a single-stranded, negative-sense mini-genome RNA virus. Zaire Ebola virus is responsible for the recent outbreak in West-Africa. Ebola viruses...

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Tumor-specific internalizing peptides or tumor-homing peptides

Can cancer cells or their microenvironment be targeted selectively to treat tumors? Yes, is appears that this is possible. A number of peptides have been reported to specifically target tumor and tumor...

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Control templates or standards for molecular DNA and RNA diagnostics

Control templates for molecular DNA/RNA diagnosticsAs the number and scope of disease-producing pathogens and their genetic variants that cause human disease have continued to increase, there has been...

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Ebola Peptides for Diagnostics and Vaccines

Ebola Peptides for Diagnostics and VaccinesPeptides derived from Ebola virus proteins can be used to study antigenicity and immunogenicity of Ebola proteins. In addition, these peptide epitopes can be...

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MicroRNAs or miRNAs as cancer biomarkers

miRNAs are a class of endogenous small RNAs approximately 22 nucleotides in size found in plants and animals including humans. miRNA's processing occurs from approximately 70 nucleotides in size...

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Disease dependent differentially expressed miRNAs

Disease dependent differentially expressed miRNAs MicroRNAs (miRNAs) are known to play important roles in diseases pathology such as infections and cancer. The recent development of high-throughput...

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