Histidine-rich peptides for nanomedicine based drugs
Histidine-rich peptides are endosomal escape agents used in nanomedicine for drug delivery. The cellular endosomal uptake pathway is known as the rate-limiting barrier for bioactive molecules....
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Peptide-conjugated Antisense Oligonucleotides for Exon Skipping Therapeutics
Peptide-conjugated antisense oligonucleotides enable exon-skipping therapeutics. Antisense Oligonucleotides (ASOs or AONs) are small single stranded chemically modified nucleic acids designed for...
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Ongoing pharmaceutical endeavor to develop orally administrable drugs...
One of the key issues discussed at the San Antonio Breast Cancer Symposium concerns drug delivery. The notion of administering drugs orally seems unconventional given that most cancer chemotherapies...
View ArticleCovid-19 Omicron's impact on humoral and cellular immunity induced by...
In recent weeks, the medical community has been confronted with the newly emerged COVID-19 coronavirus strain dubbed 'Omicron' (B.1.1.529). Given the highly unstable nature of RNA virus' genome, the...
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Primer and Probe Sets for the detection of Omicron variants
Specific RT-qPCR assays enable rapid identification of newly emerging SARS-COV-2 variants such as the Omicron (B.1.1.529) virus variant of concern. The assays target characteristic mutations in the...
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Water-soluble zinc pyrithione inhibits bacterial resistance to the antibiotic...
Multidrug-resistant gram-negative bacteria are a serious and growing risk to public health. Gram-negative bacteria can cause antibiotic-resistant infections, often leading to death. Resistance to the...
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Therapeutic Editing of Mutated RNA as a Potential Cure for Genetic Diseases
The conversion of adenosines to inosines by ADARs is known as RNA editing.RNA is the blueprint for protein production in cells. Adenosine deaminases acting on RNA (ADAR) present in cells can catalyze...
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FDA approves first radiopharmaceutical 'peptide-drug conjugate'...
Side effects continue to undermine the well-being of cancer patients undergoing therapy. To reduce side effects associated with current therapeutics, antibodies have been utilized as the delivery...
View ArticleImmune system stimulating or immuno-stimulatory motifs are present in DNA and...
Synthetic and natural RNA molecules can contain sequence motifs that stimulate the immune system. In addition to mediating RNA interference (RNAi), silencing RNAs (siRNAs) can induce the innate immune...
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Oligonucleotide Therapeutics Handbook
With the increased prevalence of diseases that have defied cures for ages such as cancer and neurodegenerative diseases as well as the resurgence of drug-resistant microbial or viral pathogens, there...
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A specific intracellular peptide delivery system for targeting cellular...
An effective drug delivery system enables the release of the active ingredient where it is most needed to achieve the desired therapeutic effect. For cellular therapeutics to work well, the precise...
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Oligonucleotide-Conjugated Antibodies for Diagnostics and Therapeutics
Oligonucleotide-conjugated antibodies are valuable tools for protein diagnostics and therapeutics. Oligonucleotide-conjugated antibodies increase the sensitivity of protein assays tremendously and...
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Peptide-drug conjugates being developed to address the side effects issue of...
pHLIP is a peptide that undergoes conformational change in the acidic milieu to translocate across cell membrane of cancer cells. A conjugate comprised of pHLIP and topoisomerase I inhibitor was...
View ArticleShuttle Peptides for Cancer Therapeutics
Shuttle peptides are peptides or peptide conjugates designed to allow the transport or delivery of therapeutic payloads, such as drugs, oligonucleotides, or proteins, through cell or tissue barriers,...
View ArticleProtease-Resistant Peptides for Targeted Cell Delivery
According to the human genome project, there are 30,000 human genes. Approximately 3,000 are disease-modifying genes, and around 3,000 are druggable genes. These numbers indicate that only 2 to 5 % of...
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Basic Bioconjugation Chemistry of Reactive Groups in Biomolecules
Chemical conjugation and cross-linking reactions depend on the reactivities of functional groups present in biomolecules and the specificities of conjugation and cross-linking reagents used. In most...
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Peptide Linkers and Linker Peptides for Antibody Drug Conjugates (ADCs),...
Peptide linkers or drug-peptide linkers enable the development of next-generation antibody-drug conjugates (ADCs) with enhanced plasma stability and function. In addition, linker peptides also allow...
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Maleimide labeling of thiolated biomolecules
The reaction of maleimides with thiol-containing biomolecules is a commonly used conjugation method. This conjugation reaction allows adding a label or cargo molecule to a protein, a peptide, or an...
View ArticleStrategies for conjugating fluorescent dyes to plasmid DNA to visually track...
'Gene therapy' originally referred to curing an inherited pathologic condition by replacing the mutated gene with the wild-type (normal) equivalent in the affected patient. Over the years, the...
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