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FANA antisense oligonucleotides allow modulation of gene expression by...
FANA antisense oligonucleotides, also called FANA ASOs, are synthetic single-stranded modified oligonucleotides that allow modulation of gene expression by enzymatic degradation of a target RNA. FANA...
View ArticleSpectra of available Fluorescent Dyes
Spectra of available Fluorescent DyesFluorescent DyeAbsEmLabelling PositionPurification OptionAlternative to5'Int3'HPSFHPLCPAGEAlexa Fluor 350 [Alexa350]346442xxx x AMCA, DyLight350, iFluor350,...
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Function and Application of 5’-Triphosphate Oligonucleotides
Synthetic oligonucleotide-based therapeutics, including antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and modified oligonucleotides, require high-quality products at high...
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Highly nuclease resistance and thermodynamically stable...
2'-O, 4'-C-Ethylene-bridged Nucleic Acids (ENA) are promising modified nucleic acids in which ethylene is bridged at the furanose sugar ring at the 2'-O and 4'-C ends to form a less strained...
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Transfection of neurons is possible with a Steryl-R8 siRNA mixture
In the endogenous regulatory process called RNA interference (RNAi), short double-stranded RNA oligonucleotides cause sequence-specific posttranscriptional silencing of genes. Small interference RNA...
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Nedosiran, a newly approved siRNA-based Therapeutic for Kidney Disease
The recent approval of Nedosiran (RIVFLOZATM) by the FDA was another landmark moment in the field of hyperoxaluria. Hyperoxaluria is increased hepatic oxalate production, leading to recurrent calcium...
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A Collection of Approved Antisense Therapeutic Drugs 2024
Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides. ASOs can alter RNA and reduce, restore, or modify protein expression through several mechanisms....
View ArticleCpG Oligonucleotides for the Development of Adjuvants
CpG oligonucleotides (CpG ODNs or CpG) are short single-stranded DNA oligonucleotides containing a cytosine guanine (CpG) motif within their sequence. The “p” in this motif refers to the phosphodiester...
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CpG Oligonucleotides for the Development of Adjuvants and Therapeutics
CpG oligonucleotides (CpG ODNs or CpG) are short single-stranded DNA oligonucleotides containing a cytosine guanine (CpG) motif within their sequence. The “p” in this motif refers to the phosphodiester...
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Asthma, CpG DNA and Toll-like Receptor-9
What is the cause of asthma?Reduced exposure in early life to microbes and microbial products is thought to cause asthma. People who were raised on farms and who attended out-of-home daycare earlier...
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Gapmer Antisense Oligonucleotides Interact with Proteins
Gapmers are short deoxyribonucleic acid-based antisense oligonucleotides. Antisense oligonucleotides are chemically modified to enhance the pharmacological properties of RNase H1-antisense...
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Enhancer RNAs add a crucial regulatory layer to the genome
Enhancer RNAs add a crucial regulatory layer to the genome. Kim et al. (2010) identified a new class of RNAs called enhancer RNAs or eRNAs. Enhancers are cis-regulatory gene elements and are crucial...
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Therapeutic Peptides for the Treatment of Type 2 Diabetes and Weight Loss
Therapeutic peptides have emerged as promising drugs for treating various medical conditions, including type 2 diabetes and weight loss. The chronic metabolic disorder Type 2 diabetes is distinguished...
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Serinol Nucleic Acid is a Xeno Nucleic Acid
Serinol nucleic acids (SNAs), a unique class of synthetic nucleic acid analogs, are designed to mimic the structure and function of natural nucleic acids (DNA and RNA). They stand out in the realm of...
View ArticleGene Knockdown Methods To Determine Gene Function!
A gene’s function can be defined by reducing or completely disrupting its normal expression. Since its discovery, interference RNA (RNAi) has offered a magic bullet to disrupt gene expression in many...
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The fluorescent analog Pyrrolo-dC allows the study of modified oligonucleotides
The fluorescent analog of deoxycytidine (C), pyrrole-deoxycytidine (pyrrole-dC, PdC), specifically base pairs with deoxyguanosine (G) and is a valuable tool for probing the structures of nucleic acid...
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Adding a G-clamp improves the thermodynamic stability of the DNA duplex
What is a G-clamp?The G-clamp, a unique molecular structure or motif, is specifically designed to interact with guanine-rich sequences in DNA or RNA oligonucleotides. It is a tricyclic analog of...
View ArticleData Technology Privacy Policy
We at Bio-Synthesis Inc. value our customers' privacy, and we are dedicated to protecting any personal data. This Policy is designed to provide you with a clear understanding of how Bio-Synthesis Inc....
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The Artificially Expanded Genetic Information System or AEGIS
An Artificially Expanded Genetic Information System (AEGIS) is a transformative concept in biotechnology and genetic engineering. It involves creating or modifying genetic systems to expand their...
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PCR Primers for Monkeypox Virus Research and Diagnostics
The monkeypox virus is the cause of the viral monkeypox disease. The monkeypox virus, a member of the Orthopoxvirus genus in the Poxviridae family, is closely related to the variola virus, which...
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