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Myokine musclin promotes exercise-induced cardiac conditioning
The protein musclin, known as osteocrin, regulates muscle metabolism and growth and is essential for exercise-induced cardiac protection. Inducing musclin signaling might serve as a novel therapeutic...
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2’-O-NMA phosphoramidites enable the synthesis of RNA mimics useful for...
Therapeutic oligonucleotides affect RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or translation. Several therapeutic oligonucleotides are now approved for clinical correction...
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Reducing off-target effects of the siRNA therapeutics via placing a...
Heart disease continues to cause a high rate of mortality in the U. S. as it accounts for ~20% of all deaths. Despite investing heavily on modifying diet, ~697,000 individuals may succumb to the...
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The efficacy of FDA-approved drug inhibiting the ‘cap snatching’ endonuclease...
With the gradual decline in the number of COVID-19 infections (total of ~103 million cases in the U. S. alone during the 3-year pandemic), the attention is returning to flu, which is projected to...
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Aptamers-Nucleic Acid-Based Molecules with Diverse Applications
Aptamers are nucleic acid-based molecules that have gained significant attention in biotechnology, medicine, and diagnostics due to their unique properties and versatile applications. These molecules...
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siRNA and the immune system
Double-stranded small interfering RNA (siRNA) silences the expression of specific genes. siRNAs have demonstrated their potential in treating various diseases and are a powerful tool for research and...
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Signaling Aptamers with specific target binding properties
Designing oligonucleotides such as aptamers with specific target binding properties widens the application range of nucleic acid-based fluorescent probes for detecting many analytes, including small...
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Thiomorpholino oligonucleotides or TMOs – An innovative class of Antisense...
Oligodeoxynucleotide, ODN analogues, are versatile biological and therapeutic agents that have various applications such as RNA interference, splice switching, aptamer binding, and antisense...
View ArticleThe antimicrobial wasp Polybia-MP1 peptide selectively kills bacterial cells!
The Polybia-MP1 peptide (IDWKKLLDAAKQIL-NH2) obtained from the venom of the social wasp Polybia paulista is highly selective of bacterial cells.The peptide exhibits broad-spectrum bacterial activity...
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Lanmodulin, a rare-earth element binding protein
Rare-earth elements, such as permanent magnets, light-emitting diodes, and phosphors, are widely used in modern technologies. However, effective separation of lanthanides is challenging. The increased...
View ArticleRare-earth element-capture peptides!
Landmodulin protein- and peptide-based ion exchange chromatography may allow the capture, separation, and purification of rare-earth elements.According to the U.S. Secretary of Energy Rick Perry,...
View ArticleHow does the cytoplasmic microtubule-based motor dynein move?
The microtubule-based motor protein cytoplasmic dynein is involved in transporting a diverse array of cargo, allowing cells to organize their contents, move, divide, and respond to stimuli. Dyneins are...
View ArticleRecent methods for the analysis of miRNA pathways
Micro-RNAs (miRNAs) are small, single-stranded, non-coding ribonucleic acids (RNAs). First discovered in 1993 in C. elegans, they are now known to take part in regulating gene expression. In recent...
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Cell-penetrating peptides for the delivery of siRNA into cells
The number of efficient delivery systems for therapeutic molecules into cells still needs to be increased. SiRNA introduced into cells drives the RNA interference (RNAi) process. Because of the high...
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Therapeutic Antisense Oligonucleotides (ASOs) and their Modifications
Antisense oligonucleotides (ASOs) are short, synthetic strands of DNA or RNA that bind to specific RNA targets and modulate gene expression. ASOs can inhibit gene expression, promote gene expression,...
View ArticleTyrosine- or Y-clicking of oligonucleotides and proteins useful for...
Click reactions are high-yielding, specific, and practical chemical reactions now applied in various chemical fields, including materials science, bioconjugation, pharmaceuticals, and nanotechnology....
View ArticleTherapeutic tiny or short modified antisense oligonucleotides (Tiny ASOs) can...
Tiny antisense oligonucleotides and short, synthetic, antisense oligonucleotides, when forming base pairs with regulatory RNA, disrupt the normal RNA–RNA base-pairing or protein–RNA binding...
View ArticleRNA Interference Studies in Cell Cultures
RNA interference allows the knockdown of gene expression in cells, for example, in cell cultures. During RNA interference (RNAi), double-stranded RNA (dsRNA) induces sequence-specific gene silencing by...
View ArticleGlycol nucleic acids (GNAs) and their applications
Glycol Nucleic Acids (GNAs), sometimes also called glycerol nucleic acids, are unnatural nucleic acid analogs, based on a glycol monomer unit, with an acyclic three-carbon sugar-phosphate backbone that...
View ArticleWhat are Threofuranosyl Nucleotides or TNAs?
Threofuranosyl nucleotides are the building blocks of α-l-threose nucleic acids (TNAs). The TNA moiety has one less atom in its backbone than the DNA backbone. The B-family polymerase Kod-RI, a...
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