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Synthesis of circular oligonucleotides
Synthesis of circular oligonucleotidesThe polymerase chain reaction (PCR) is a technique that allows amplification of nucleic acids in-vitro. However, the reaction produces linear products. Many forms...
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Enzymatic synthesis of Circular Oligonucleotides
Enzymatic Synthesis of Circular Oligonucleotides Chemical solid phase and solution phase synthesis methods allow the synthesis of circular oligonucleotides, both for the production of circular DNA and...
View ArticleApplications for circular oligonucleotides
Applications for circular oligonucleotides Circularized or circular single-stranded deoxyribosnucleotides (ssDNAs), also often just called circular oligonucleotides, are more resistant to the attack...
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Plasmids are autonomous circular oligonucleotides
Plasmids are autonomous circular oligonucleotides Modern recombinant technology produces large numbers of identical DNA molecules. The technology relays on the formation of 3’ -> 5’ phosphodiester...
View ArticleA circular ribo-oligonucleotide or RNA is a noncoding RNA
A circular ribo-oligonucleotide or RNA is a noncoding RNA Circular RNAs (circRNAs), or circular ribo-oligonucleotides, were recently added to the growing list of noncoding RNAs. However, since the...
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Telomere repeat sequences
Telomere repeat sequences Telomeres are DNA structures at the ends of eukaryotic chromosomes that protect them from degradation and DNA repair activities. Initially, telomeres were defined functionally...
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PEGylation of therapeutic proteins
PEGylation of Therapeutic Proteins Therapeutic proteins such as monoclonal antibodies and cytokines, after delivery to the body, are eliminated by proteolysis and clearance in the kidney or liver, a...
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What are Circular Oligonucleotides?
What are Circular Oligonucleotides?Circular oligonucleotides are covalently closed singular DNA or RNA strands that are resistant to degradation by many cellular DNA and RNA decay machineries. Models...
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Synthesis of circular oligonucleotides
Synthesis of circular oligonucleotidesThe control of biomolecular functions has become an important research subject in biology and biomedicine in recent years. Chemical approaches useful for this...
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Enzymatic synthesis of Circular Oligonucleotides
Enzymatic Synthesis of Circular Oligonucleotides Chemical solid phase and solution phase synthesis methods allow the synthesis of circular oligonucleotides, both for the production of circular DNA and...
View ArticleApplications for circular oligonucleotides
Applications for circular oligonucleotides Circularized or circular single-stranded deoxyribosnucleotides (ssDNAs), also often just called circular oligonucleotides, are more resistant to the attack...
View ArticleClik here to view.
Plasmids are autonomous circular oligonucleotides
Plasmids are autonomous circular oligonucleotides Modern recombinant technology produces large numbers of identical DNA molecules. The technology relays on the formation of 3’ -> 5’ phosphodiester...
View ArticleA circular ribo-oligonucleotide or RNA is a noncoding RNA
A circular ribo-oligonucleotide or RNA is a noncoding RNA Circular RNAs (circRNAs), or circular ribo-oligonucleotides, were recently added to the growing list of noncoding RNAs. However, since the...
View ArticleExtrachromosomal circular DNA is found in Eukaryotic Cells
Extrachromosomal circular DNA is found in Eukaryotic Cells Various eukaryotic cells, including human cells, contain extrachromosomal circular DNA (eccDNA). Genomic plasticity, the ability of...
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Extrachromosomal circular DNA is found in Eukaryotic Cells Various eukaryotic cells, including human cells, contain extrachromosomal circular DNA (eccDNA). Genomic plasticity, the ability of...
View ArticleZINC FINGER PEPTIDES
Zinc finger peptides Zinc fingers are polypeptides that are part of small protein domains in which the zinc complex structure contributes to the overall stability of the domain. However, zinc fingers...
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BNA Based Digital PCR application in modern research
Digital PCRDigital PCR (dPCR) enables accurate, highly sensitive quantification of nucleic acids (DNA/RNA). Traditional PCR is an end-point analysis that is semi-quantitative because the amplified...
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Protein Characterization and Purification Methods
Protein Characterization and Purification Methods Protein characterization involves the use of experimental methods that allow for the detection and isolation of a protein and its purification, as well...
View ArticleHarmonisation Guidelines for Pharmaceuticals for Human Use
Harmonisation Guidelines for Pharmaceuticals for Human Use or Guidelines for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use The mission of the "International...
View ArticleGuidelines for Protein Purification
Guidelines for Protein Purification Protein characterization involves the use of experimental methods that allow for the detecting and isolation of a protein and its purification. The characterization...
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