Disease dependent differentially expressed miRNAs

miRNAs

Disease Types

Up/Down-regulated

Reference

let-7a, let-7b, let-7c, let-7d, let-7g, miR-16, miR-23a, miR-23b, miR-26a, miR-92, miR-99a, miR-103, miR-125a, miR-125b, miR-143, miR-145, miR-195, miR-199a, miR-199a, miR-221, miR-222, miR-497

prostate cancer

down-regulated

▼

Porkka KP, Pfeiffer MJ, Waltering KK, Vessella RL, Tammela TL, Visakorpi T: MicroRNA expression profiling in prostate cancer. Cancer Res 2007, Jul 1; 67(13):6130-5.

http://cancerres.aacrjournals.org/content/67/13/6130.abstract

miR-202, miR-210, miR-296, miR-320, miR-370, miR-373, miR-498, miR-503

prostate cancer

up-regulated

▲

Porkka KP, Pfeiffer MJ, Waltering KK, Vessella RL, Tammela TL, Visakorpi T: MicroRNA expression profiling in prostate cancer. Cancer Res 2007, Jul 1; 67(13):6130-5.       

miR-16, miR-92a, miR-103, miR-107, miR-197, miR-34b, miR-328, miR-485-3p, miR-486-5p, miR-92b, miR-574-3p, miR-636, miR-640, miR-766, miR-885-5p

prostate cancer

up-regulated

▲

Lodes MJ, Caraballo M, Suciu D, Munro S, Kumar A, Anderson B: Detection of cancer with serum miRNAs on an oligonucleotide microarray. PLoS One 2009, Jul 14; 4 (7):e6229.Published: July 14, 2009.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006229

miR-21, miR-155, miR-221

Pancreatic cancer

up-regulated

▲

Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu CG, Bhatt D, Taccioli C, Croce CM: MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis JAMA 2007, 297(17):1901-1908. (doi:10.1001/jama.297.17.1901). http://www.ncbi.nlm.nih.gov/pubmed/17473300

miR-155, miR-21

colon, lung, breast,stomach, prostate

up-regulated

▲

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri A, Musiani P, Volinia S, Nenci I, Calin GA, Querzzoli P: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065–7070. http://www.ncbi.nlm.nih.gov/pubmed/16103053

Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006, Feb 14; 103(7):2257-2261. Epub 2006 Feb 3.

http://www.ncbi.nlm.nih.gov/pubmed/16461460

miR-142-5p, miR-369-3p, miR-215

lung cancer

up-regulated

▲

Baffa R, Fassan M, Volinia S, O'Hara B, Liu CG, Palazzo JP, Gardiman M, Rugge M, Gomella LG, Croce CM, Rosenberg A: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol 2009, Jun 1.

http://www.ncbi.nlm.nih.gov/pubmed/19593777.

miR-373

lung cancer

down- regulated

▼

Baffa et al. 2009

miR-30d, miR-125b, miR-26a, miR-30a-5p

thyroid anaplastic carcinomas

down- regulated

▼

Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM, Fusco A: Specific microRNAs are down regulated in human thyroid anaplastic carcinomas. Oncogene 2007, Nov 29; 26(54):7590-7595. Epub 2007 Jun 11.

http://www.ncbi.nlm.nih.gov/pubmed/17563749.

miR-10b, miR-125b, miR-145

breast cancer

down- regulated

▼

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri A, Musiani P, Volinia S, Nenci I, Calin GA, Querzzoli P: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065–7070.

http://www.ncbi.nlm.nih.gov/pubmed/16103053.

miR-27a, miR-96, miR-182

breast cancer

up-regulated

▲

Guttilla IK, White BA: Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009 Aug 28;284(35):23204-16.

miR-21, miR-155

breast cancer

up-regulated

▲

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri A, Musiani P, Volinia S, Nenci I, Calin GA, Querzzoli P: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065–7070.

http://www.ncbi.nlm.nih.gov/pubmed/16103053

miR-21

breast cancer

up-regulated

▲

Huang GL, Zhang XH, Guo GL, Huang KT, Yang KY, Shen X, You J, Hu XQ: Clinical significance of miR-21 expression in breast cancer: SYBR-Green I-based real-time RT-PCR study of invasive ductal carcinoma. Oncol Rep. 2009, Mar 21; (3):673-9.

http://www.ncbi.nlm.nih.gov/pubmed/19212625       

miR-30b, miR148a

breast cancer

up-regulated

▲

Baffa R, Fassan M, Volinia S, O'Hara B, Liu CG, Palazzo JP, Gardiman M, Rugge M, Gomella LG, Croce CM, Rosenberg A: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol. 2009, 219(2):214-21.

http://www.ncbi.nlm.nih.gov/pubmed/19593777

miR-205

breast cancer

down-regulated

▼

Baffa et al. 2009.

miR-142-5p, miR-29b, miR-30b

bladder cancer

up-regulated

Baffa et al. 2009.

miR-145, miR-143, miR-320

bladder cancer

down- regulated

▼

Baffa et al. 2009.

miR-138, miR-125b

colon cancer

up-regulated

Baffa et al. 2009.

miR-17, miR-106a

colon cancer

down- regulated

▼

Baffa et al. 2009.

hsa-miR-205

head and neck cancer

up-regulated

▲

Tran N, McLean T, Zhang X, Zhao CJ, Thomson JM, O’Brien C, Rose B: MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun 2007, 358:12–17.

http://www.ncbi.nlm.nih.gov/pubmed/17475218.

miR-21, miR-221

brain cancer

up-regulated

▲

Ciafre, S.A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.G., Sabatino, G., Negrini, M., Maira, G., Croce, C.M., Farace, and M.G: Extensive modulation of a set of microRNAs in primary glioblastomas. Biochem Biophys Res Commun 2005, 334:1351–1358.

http://www.sciencedirect.com/science/article/pii/S0006291X0501481

miR-9-2, miR-10b, miR-21, miR-25, miR-123, miR-125b-1, miR-125b-2,  miR-130a, miR-221

glioblastomas

up-regulated

▲

Ciafre et al., 2005

miR-10b, miR-21, miR-26a, miR-383, miR-451, miR-486, miR-516-3p, miR-519d

glioblastomas

up-regulated

▲

Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S: Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 2008, 68:9125–9130. doi:10.1158/0008-5472.CAN-08-2629.

http://www.ncbi.nlm.nih.gov/pubmed/19010882

miR-7, miR-29b, miR-31, miR-101, miR-107, miR-124, miR-124-2, miR-128-1, miR-129, miR-132, miR-133a , miR-133b, miR-137

glioblastomas

down- regulated

▼

Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG: miR-124 and miR-137 inhibit proliferation of glioblastoma multiform cells and induce differentiation of brain tumor stem cells. BMC Med 2008, 6:14. doi:10.1186/1741-7015-6-14.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443372/

miR-138, miR-139, miR-149, miR-153, miR-154, miR-185, miR-187, miR-203, miR-218, miR-323, miR-328, miR-330

glioblastomas

down- regulated

▼

Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, Amariglio N, Rechavi G, Givol D: MIR-451 and Imatinib mesylate inhibit tumor growth of glioblastoma stem cells. Biochem Biophys Res Commun 2008, 376:86–90. doi:10.1016/j.bbrc. 2008.08.107.

http://www.ncbi.nlm.nih.gov/pubmed/18765229

miR-15, miR-16

chronic lymphocytic leukemia (CLL)

down- regulated

▼

Calin GA: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002, 99: 15524–15529.

http://www.ncbi.nlm.nih.gov/pubmed/12434020       

miR-150, miR-155           

CLL

up-regulated

▲

Bartels CL, Tsongalis GJ: MicroRNAs: novel biomarkers for human cancer. Clin Chem 2009, Apr; 55(4):623-31. Epub 2009 Feb 26. http://www.ncbi.nlm.nih.gov/pubmed/19246618

miR-143, miR-145

colorectal neoplasia

down- regulated

▼

Michael MZ, O´Connor SM, Van Holst Pellekaan NG, Young GP, James RJ: Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 2003, 1:882-891.

http://www.ncbi.nlm.nih.gov/pubmed/14573789

miR-18, miR-224

hepato. Carcinoma

up- regulated

▲

Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-timorous tissues. Oncogene 2006, 25:2537–2545.

http://www.ncbi.nlm.nih.gov/pubmed/16331254

miR-199, miR-195, miR-200, miR-125

hepato. Carcinoma

down- regulated

▼

Murakami et al., 2006

miR-221, miR-222, miR-146, miR-181

papillary thyroid carcinoma

up-regulated

▲

He H, Jazdzewski K, Li W, Liyanarachchi S, Nagi R, Volinia S, Calin GA: The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA 2005b, 102:19075-19080.

http://www.ncbi.nlm.nih.gov/pubmed/16365291

Pallante P, Visone R, Ferracin M, Ferraro A, Berlingieri MT, Troncone G, Chiappetta G, Liu CG, Santoro M, Negrini M: Deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer 2006, 13:497–508.

http://www.ncbi.nlm.nih.gov/pubmed/16728577

miR-372, miR-373

testicular germ cell tumors

up-regulated

▲

Voorhoeve PM, le Sage C, Schrier M: A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006, 124:1169-1181.

http://www.ncbi.nlm.nih.gov/pubmed/16564011

miR-31, miR-96, miR-135b, miR-183

colorectal cancer

up-regulated

▲

Bartels and Tsongalis 2009.

miR-48, miR-135b, miR-133b

colorectal cancer

down- regulated

▼

Bartels and Tsongalis 2009.

let-7b, let-7 g, miR-9, miR-21, miR-26a, miR-30a-3p, miR-30a-5p, miR-31, miR-96, miR-124b, miR-132, miR-135a, miR-135b, miR-141, miR-142-3p, miR-142-5p, miR-181a, miR-181b, miR-182, miR-183, miR-194, miR-200a, miR-200b, miR-200c, miR-203, miR-205, miR-215, miR-219, miR-320, miR-338, miR-372

colorectal cancer

up-regulated

▲

Yang L, Belaguli N, Berger DH: MicroRNA and Colorectal Cancer. World J Surg 2009, 33:638–646.

let-7a, miR-10a, miR-15b, miR-23a, miR-25, miR-27a, miR-27b, miR-30c, miR-107, miR-124a, miR0125a, miR-125b, miR-127, miR-130a, miR-133a, miR-133b, miR-134, miR-137, miR-143, miR-145, miR-147, miR-154, miR-191, miR-199a, miR-199b, miR-214, miR-296, miR-299, miR-337, miR-339, miR-342, miR-368, miR-370, miR-582

colorectal cancer

down- regulated

▼

Yang L, Belaguli N, Berger DH: MicroRNA and Colorectal Cancer. World J Surg 2009, 33:638–646.

miR-224, miR-18 and pre-miR-P18, miR-221

Hepatocellular cancer

up-regulated

▲

Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-timorous tissues. Oncogene 2006, 25:2537–2545.

http://www.ncbi.nlm.nih.gov/pubmed/16331254

Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M: MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.  Oncogene 2008, Sep 25; 27(43):5651-61 Epub 2008 Jun 2.

http://www.ncbi.nlm.nih.gov/pubmed/18521080

miR-199a, miR-199a*, miR-200a, miR-125a, miR-195, miR-125b

Hepatocellular cancer

down- regulated

▼

Murakami et al., 2006.

Li W, Xie L, He X, Li J, Tu K, Wei L, Wu J, Guo Y, Ma X, Zhang P, Pan Z, Hu X, Zhao Y, Xie H, Jiang G, Chen T, Wang J, Zheng S, Cheng J, Wan D, Yang S, Li Y, Gu J: Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer 2008, Oct 1; 123(7):1616-22.

http://www.ncbi.nlm.nih.gov/pubmed/18649363