Spectra of available Fluorescent Dyes
Spectra of available Fluorescent DyesFluorescent DyeAbsEmLabelling PositionPurification OptionAlternative to5'Int3'HPSFHPLCPAGEAlexa Fluor 350 [Alexa350]346442xxx x AMCA, DyLight350, iFluor350,...
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Function and Application of 5’-Triphosphate Oligonucleotides
Synthetic oligonucleotide-based therapeutics, including antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and modified oligonucleotides, require high-quality products at high...
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Highly nuclease resistance and thermodynamically stable...
2'-O, 4'-C-Ethylene-bridged Nucleic Acids (ENA) are promising modified nucleic acids in which ethylene is bridged at the furanose sugar ring at the 2'-O and 4'-C ends to form a less strained...
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Transfection of neurons is possible with a Steryl-R8 siRNA mixture
In the endogenous regulatory process called RNA interference (RNAi), short double-stranded RNA oligonucleotides cause sequence-specific posttranscriptional silencing of genes. Small interference RNA...
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Nedosiran, a newly approved siRNA-based Therapeutic for Kidney Disease
The recent approval of Nedosiran (RIVFLOZATM) by the FDA was another landmark moment in the field of hyperoxaluria. Hyperoxaluria is increased hepatic oxalate production, leading to recurrent calcium...
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A Collection of Approved Antisense Therapeutic Drugs 2024
Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides. ASOs can alter RNA and reduce, restore, or modify protein expression through several mechanisms....
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CpG Oligonucleotides for the Development of Adjuvants and Therapeutics
CpG oligonucleotides (CpG ODNs or CpG) are short single-stranded DNA oligonucleotides containing a cytosine guanine (CpG) motif within their sequence. The “p” in this motif refers to the phosphodiester...
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Asthma, CpG DNA and Toll-like Receptor-9
What is the cause of asthma?Reduced exposure in early life to microbes and microbial products is thought to cause asthma. People who were raised on farms and who attended out-of-home daycare earlier...
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Gapmer Antisense Oligonucleotides Interact with Proteins
Gapmers are short deoxyribonucleic acid-based antisense oligonucleotides. Antisense oligonucleotides are chemically modified to enhance the pharmacological properties of RNase H1-antisense...
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Enhancer RNAs add a crucial regulatory layer to the genome
Enhancer RNAs add a crucial regulatory layer to the genome. Kim et al. (2010) identified a new class of RNAs called enhancer RNAs or eRNAs. Enhancers are cis-regulatory gene elements and are crucial...
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